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NOX4/ROS can downregulate the antioxidant NRF2/HO1 pathway and increase TGF-β1, differentiation of fibroblasts into myofibroblasts, fibronectin and collagen IV expression, tubular cell apoptosis, and renal interstitial fibrosis [138]

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doi: 10.1038/nm.3955 [DOI] [PMC free article] [PubMed] [Google Scholar] 73